Badawy, Abdel-Hameed A.Software prefetching and locality optimizations are two techniques for overcoming the speed gap between processor and memory known as the memory wall as suggested by Wulf and Mckee. This thesis evaluates the impact of memory trends on the effectiveness of software prefetching and locality optimizations for three types of applications: regular scientific codes, irregular scientific codes, and pointer-chasing codes. For many applications, software prefetching outperforms locality optimizations when there is sufficient bandwidth in the underlying memory system, but locality optimizations outperform software prefetching when the underlying memory system doesn't provide sufficient bandwidth. The break-even point, or equivalently the crossover bandwidth point, occurs at roughly 2.4 GBytes/sec , for 1 GHz processors on today's memory systems, and will increase on future memory systems. This thesis also studies the interactions between software prefetching and locality optimizations when applied in concert. Naively combining the two techniques provides a more robust application performance in the face of variations in memory bandwidth and/or latency, but does not yield additional performance gains. In other words, the performance won't be better than the best performance of the two techniques alone. Also, several algorithms are proposed and evaluated to better combine software prefetching and locality optimizations, including an enhanced tiling algorithm, padding for software prefetching, and index prefetching. (Also UMIACS-TR-2002-72)en-USTechnical Report