Keyser, Donna JPincus, Harold AlanThomas, Stephen BCastle, NicholasDembosky, JacobFirth, RaymondGreenberg, MichaelPollack, Nancy KaczynskiReis, Evelyn CohenSansing, Veronica VScholle, SarahLocal efforts to redesign systems of care offer fertile ground for community-based participatory research approaches to take hold and flourish. Drawing on the experiences of a learning collaborative of maternal and child healthcare stakeholders in Allegheny County, Pennsylvania, this article describes 8 action steps for operationalizing key community-based participatory research principles in the context of local systems change. Highlights of the subsequent evolution of the collaborative and its work are provided, as well as comments regarding the generalizability and usefulness of this approach for other public health and community stakeholders who are interested in mobilizing collaborative action for systems change.Public HealthPracticecommunity-based participatory researchlocal collaborativematernal and child healthcaresystems changeArticle