Wiehe, S. E.Aalsma, M. C.Liu, G. C.Fortenberry, J. D.OBJECTIVES: We examined associations between perceived racial/ethnic discrimination, gender, and cigarette smoking among adolescents. METHODS: We examined data on Black and Latino adolescents aged 12 to 19 years who participated in the Moving to Opportunity study (N = 2561). Perceived discrimination was assessed using survey items asking about unfair treatment because of race/ethnicity in the prior 6 months. We used logistic regression to investigate associations between discrimination and smoking, stratified by gender and controlling for covariates. RESULTS: One fourth of adolescents reported that discrimination had occurred in at least 1 location. Discrimination was associated with increased odds of smoking among boys (odds ratio [OR] = 1.9; 95% confidence interval [CI] = 1.2, 3.0) and decreased odds among girls (OR = 0.6; 95% CI = 0.3, 1.1). Discrimination at school or work contributed to associations for girls (OR = 0.3; 95% CI = 0.1, 0.9), and discrimination at shops (OR = 2.0; 95% CI = 1.1, 3.8) and by police (OR = 2.0; 95% CI = 1.2, 3.4) contributed to associations for boys. CONCLUSIONS: Associations between discrimination and smoking differ by gender. Girls' decreased smoking in higher-discrimination settings may be a result of protective factors associated with where they spend time. Boys' increased smoking in higher-discrimination settings may reflect increased stress from gender-specific targeting by police and businesses.Prenatal & Pediatric HealthSmoking & Tobacco UseResearchracial/ethnic discriminationgendercigarette smokingadolescentsArticle