Aute, Vikrant ChandramohanEngineering design optimization often involves complex computer simulations. Optimization with such simulation models can be time consuming and sometimes computationally intractable. In order to reduce the computational burden, the use of approximation-assisted optimization is proposed in the literature. Approximation involves two phases, first is the Design of Experiments (DOE) phase, in which sample points in the input space are chosen. These sample points are then used in a second phase to develop a simplified model termed as a metamodel, which is computationally efficient and can reasonably represent the behavior of the simulation response. The DOE phase is very crucial to the success of approximation assisted optimization. This dissertation proposes a new adaptive method for single and multiresponse DOE for approximation along with an approximation-based framework for multilevel performance evaluation and design optimization of air-cooled heat exchangers. The dissertation is divided into three research thrusts. The first thrust presents a new adaptive DOE method for single response deterministic computer simulations, also called SFCVT. For SFCVT, the problem of adaptive DOE is posed as a bi-objective optimization problem. The two objectives in this problem, i.e., a cross validation error criterion and a space-filling criterion, are chosen based on the notion that the DOE method has to make a tradeoff between allocating new sample points in regions that are multi-modal and have sensitive response versus allocating sample points in regions that are sparsely sampled. In the second research thrust, a new approach for multiresponse adaptive DOE is developed (i.e., MSFCVT). Here the approach from the first thrust is extended with the notion that the tradeoff should also consider all responses. SFCVT is compared with three other methods from the literature (i.e., maximum entropy design, maximin scaled distance, and accumulative error). It was found that the SFCVT method leads to better performing metamodels for majority of the test problems. The MSFCVT method is also compared with two adaptive DOE methods from the literature and is shown to yield better metamodels, resulting in fewer function calls. In the third research thrust, an approximation-based framework is developed for the performance evaluation and design optimization of novel heat exchangers. There are two parts to this research thrust. First, is a new multi-level performance evaluation method for air-cooled heat exchangers in which conventional 3D Computational Fluid Dynamics (CFD) simulation is replaced with a 2D CFD simulation coupled with an e-NTU based heat exchanger model. In the second part, the methods developed in research thrusts 1 and 2 are used for design optimization of heat exchangers. The optimal solutions from the methods in this thrust have 44% less volume and utilize 61% less material when compared to the current state of the art microchannel heat exchangers. Compared to 3D CFD, the overall computational savings is greater than 95%.DissertationEngineering, MechanicalDOEgenetic algorithmheat exchangerskrigingoptimization