Kafri, DvirQuantum information science uses the distinguishing features of quantum mechanics for novel information processing tasks, ranging from metrology to computation. This manuscript explores multiple topics in this field. We discuss implementations of hybrid quantum systems composed of trapped ions and superconducting circuits, protocols for detecting signatures of entanglement in small and many-body systems, and a proposal for ground state preparation in quantum Hamiltonian simulators.enDissertationPhysicsEntanglementHybrid quantum systemsQuantum mechanicsQuantum simulators