Stall, RonMills, Thomas CWilliamson, JohnHart, TrevorGreenwood, GregPaul, JayPollack, LanceBinson, DianeOsmond, DennisCatania, Joseph AObjectives. We measured the extent to which a set of psychosocial health problems have an additive effect on increasing HIV risk among men who have sex with men (MSM). Methods. We conducted a cross-sectional household probability telephone sample of MSM in Chicago, Los Angeles, New York, and San Francisco. Results. Psychosocial health problems are highly intercorrelated among urban MSM. Greater numbers of health problems are significantly and positively associated with high-risk sexual behavior and HIV infection. Conclusions. AIDS prevention among MSM has overwhelmingly focused on sexual risk alone. Other health problems among MSM not only are important in their own right, but also may interact to increase HIV risk. HIV prevention might become more effective by addressing the broader health concerns of MSM while also focusing on sexual risks.Public HealthHIV/AidsHealth Risk FactorsSexual HabitsStressResearchpsychosocialHIVAIDSmenmaleMSMArticle