THE ROLE OF NEUROGENIN2 AND NEUROD1, AND THEIR DOWNSTREAM TARGETS, IN TRIGEMINAL GANGLION DEVELOPMENT

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dc.contributor.advisorTaneyhill, Lisa Aen_US
dc.contributor.authorBina, Parinazen_US
dc.contributor.departmentAnimal Sciencesen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2022-09-27T05:46:08Z
dc.date.available2022-09-27T05:46:08Z
dc.date.issued2022en_US
dc.description.abstractThe trigeminal ganglion contains the cell bodies of sensory neurons comprising cranial nerve V and functions to relay information related to pain, touch, and temperature from the face and head to the central nervous system. Like other cranial ganglia, the trigeminal ganglion is composed of neuronal derivatives of two critical embryonic cell types, neural crest cells and placode cells. Neurogenesis within the cranial ganglia is promoted by Neurogenin2, which is expressed in trigeminal placode cells and their neuronal derivatives, and transcriptionally activates neuronal differentiation genes like Neuronal Differentiation 1 (or NeuroD1). Other targets downstream of Neurogenin2 and NeuroD1 include Drebrin1 and Stathmin2, cell polarity and cytoskeletal regulators that mediate changes in neuron cell shape during neurogenesis. Little is known, however, about the role of Neurogenin2, NeuroD1, and their downstream signaling pathways during trigeminal gangliogenesis in the chick embryo. By depleting Neurogenin2 and NeuroD1 from chick trigeminal placode cells with morpholino antisense oligonucleotides, we examined how these proteins influence chick trigeminal ganglion development. Additionally, we identified the expression of Drebrin1 and Stathmin2 in trigeminal ganglion neurons. Taken together, our results highlight, for the first time, functional roles for Neurogenin2 and NeuroD1 during chick trigeminal gangliogenesis. These studies will not only improve our understanding of the molecular mechanisms underlying trigeminal ganglion development, but may also provide insight into human and animal diseases of the peripheral nervous system.en_US
dc.identifierhttps://doi.org/10.13016/pphx-h4ed
dc.identifier.urihttp://hdl.handle.net/1903/29389
dc.language.isoenen_US
dc.subject.pqcontrolledAnimal sciencesen_US
dc.subject.pquncontrolledDevelopmenten_US
dc.subject.pquncontrolledEmbryoen_US
dc.subject.pquncontrolledNeuroD1en_US
dc.subject.pquncontrolledNeurogenesisen_US
dc.subject.pquncontrolledNeurogeninen_US
dc.subject.pquncontrolledTrigeminal ganglionen_US
dc.titleTHE ROLE OF NEUROGENIN2 AND NEUROD1, AND THEIR DOWNSTREAM TARGETS, IN TRIGEMINAL GANGLION DEVELOPMENTen_US
dc.typeThesisen_US

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