Bacteria-mucus interactions & their role in chronic lung infections

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dc.contributor.advisorJoyer, Katherine
dc.contributor.advisorDuncan, Gregg
dc.contributor.authorCurry, Keyona
dc.date.accessioned2020-04-26T23:43:56Z
dc.date.available2020-04-26T23:43:56Z
dc.date.issued2020
dc.descriptionObstructive lung diseases such as cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD) and asthma are characterized by impaired mucus clearance. For 60-70% of adults with CF Pseudomonas aeruginosa is the primary pathogen responsible for mortality in these patients.1 Understanding the interplay between this pathogen and mucus could lead to superior methods of drug design and delivery for the treatment of CF. In this work, we explored how P. aeruginosa affects mucus hydrogel assembly and the influence of the mucus gel on bacterial growth. Using multiple particle tracking microrheology and monitoring bacterial growth in a mucin-based we systematically examined each part of the system . We have observed that P. aeruginosa affect mucus gel assembly by prolonging the gelation process of mucin-based hydrogels. Also we found that P. aeruginosa growth in hydrogels was two times slower than P. aeruginosa grown in media. The results of this work provided a deeper understanding of how P. aeruginosa affects airway mucus in patients with cystic fibrosis.en_US
dc.description.sponsorshipNational Science Foundation (NSF), National Institutes of Health (NIH), Oak Ridge Associated Universities (ORAU), Burroughs Wellcome Fund, Cystic Fibrosis Foundation, University System of Maryland, University of Marylanden_US
dc.identifierhttps://doi.org/10.13016/vfej-no8s
dc.identifier.urihttp://hdl.handle.net/1903/25899
dc.relation.isAvailableAtMaryland Center for Undergraduate Research
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtUniversity of Maryland (College Park, Md)
dc.subjectBioengineeringen_US
dc.subjectENGRen_US
dc.subjectCurryen_US
dc.subjectLSAMPen_US
dc.subjectBacteriaen_US
dc.subjectHydrogelen_US
dc.titleBacteria-mucus interactions & their role in chronic lung infectionsen_US
dc.typePresentationen_US

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Bacteria-mucus interactions & their role in chronic lung infections
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