Towards Integrated Fluorescence Sensing

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2008-01-11

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This thesis is an account of ongoing efforts in the Integrated Biomorphic Information Systems Laboratory and the Laboratory for MicroTechnologies towards the implementation of integrated microfabricated biosensing platforms with on-chip fluorescence detection capability. The first chapter is a published, exhaustive, and critical review of state-of-the-art microfluorometers, and it offers a set of performance metrics for evaluating sensors of different architectures. The second chapter consists of material from two journal papers, currently in preparation, in which the development of a polymeric optical filter material for UV fluorescence spectroscopy is presented and its integration with a CMOS active pixel sensor (APS) discussed. The third chapter, which is also an archival publication, presents initial efforts towards achieving high-sensitivity CMOS photodetectors for photon counting-based fluorescence assays in integrated platforms.

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