Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

dc.contributor.authorLangmead, Ben
dc.contributor.authorTrapnell, Cole
dc.contributor.authorPop, Mihai
dc.contributor.authorSalzberg, Steven L
dc.date.accessioned2021-11-30T15:51:37Z
dc.date.available2021-11-30T15:51:37Z
dc.date.issued2009-03-04
dc.description.abstractBowtie is an ultrafast, memory-efficient alignment program for aligning short DNA sequence reads to large genomes. For the human genome, Burrows-Wheeler indexing allows Bowtie to align more than 25 million reads per CPU hour with a memory footprint of approximately 1.3 gigabytes. Bowtie extends previous Burrows-Wheeler techniques with a novel quality-aware backtracking algorithm that permits mismatches. Multiple processor cores can be used simultaneously to achieve even greater alignment speeds. Bowtie is open source http://bowtie.cbcb.umd.edu .en_US
dc.description.urihttps://doi.org/10.1186/gb-2009-10-3-r25
dc.identifierhttps://doi.org/10.13016/kiy1-gyzy
dc.identifier.citationLangmead, B., Trapnell, C., Pop, M. et al. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol 10, R25 (2009).en_US
dc.identifier.urihttp://hdl.handle.net/1903/28174
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isAvailableAtCollege of Computer, Mathematical & Natural Sciencesen_us
dc.relation.isAvailableAtComputer Scienceen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectAdditional Data Fileen_US
dc.subjectCentral Processing Uniten_US
dc.subjectHuman Reference Genomeen_US
dc.subjectMemory Footprinten_US
dc.subjectNCBI Short Read Archiveen_US
dc.titleUltrafast and memory-efficient alignment of short DNA sequences to the human genomeen_US
dc.typeArticleen_US

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