Mapping the heterogeneity of the human senescent proteome

dc.contributor.advisorBasisty, Nathan
dc.contributor.authorCunningham, Ana S.G.
dc.contributor.authorTsitsipatis, Dimitrios
dc.contributor.authorAnerillas, Carlos
dc.contributor.authorBanarjee, Reema
dc.contributor.authorGorospe, Myriam
dc.contributor.authorHerman, Allison B.
dc.contributor.authorSingleton, Andrew
dc.contributor.authorMazan-Mamczarz, Krystyna
dc.contributor.authorQi, Andy
dc.contributor.authorYi, Ziyi
dc.contributor.authorHao, Ying
dc.date.accessioned2024-04-17T13:43:51Z
dc.date.available2024-04-17T13:43:51Z
dc.date.issued2023-08-04
dc.description.abstractCellular senescence is a unique response to sublethal stress characterized by at least two elements: persistent cell cycle arrest and a senescence-associated secretory phenotype (SASP). Recent evidence suggests a close link between senescence and aging, as selective elimination of senescent cells in mice improves longevity and overall health. Therefore, there is increased interest in identifying markers to develop drugs (senolytics) that selectively eliminate senescent cells without harming healthy, proliferating cells. However, senescent phenotypes vary across cell types and inducers, creating a need for tissue-specific markers of senescence. To this “senescence catalog” has three aims: 1) Identify protein and RNA markers of senescence; 2) Compare across models to find overlapping markers; and 3) Validate markers with scRNA-seq and IHC in culture and in mice.
dc.description.sponsorshipNational Institutes of Health (NIH) Intramural Research Training Award (IRTA) NIH Intramural Research Program (IRP)
dc.identifierhttps://doi.org/10.13016/yeoa-b4lu
dc.identifier.urihttp://hdl.handle.net/1903/32486
dc.language.isoen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtUniversity of Maryland (College Park, Md)
dc.relation.isAvailableAtOffice of Undergraduate Research
dc.subjectbiology
dc.subjectCMNS
dc.subjectNIH
dc.subjectaging
dc.titleMapping the heterogeneity of the human senescent proteome
dc.typePresentation
local.equitableAccessSubmissionNo

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
AC NIH poster final.pptx
Size:
2.55 MB
Format:
Microsoft PowerPoint 2007 Presentation
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.55 KB
Format:
Item-specific license agreed upon to submission
Description: