Association between increased hepatic lipid storage and impaired hepatic mitochondrial function in ovariectomized mice

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dc.contributor.advisorSpangenburg, Espen Een_US
dc.contributor.authorValencia, Ana Patriciaen_US
dc.contributor.departmentKinesiologyen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2012-10-10T11:18:58Z
dc.date.available2012-10-10T11:18:58Z
dc.date.issued2012en_US
dc.description.abstractReduced ovarian function is associated with development of the metabolic syndrome (MetS). Increased risk for MetS is strongly linked to hepatic metabolic dysfunction. However, at this time few studies have examined metabolic function of hepatic tissue under conditions of reduced ovarian function. The purpose of this study was to determine if ovariectomy (OVX) impaired hepatic mitochondrial function and its potential association with sirtuin (SIRT) function. Female C57BL/6 mice were divided into two groups (SHAM, OVX). Hepatic mitochondrial function was measured by assessing oxygen consumption, reactive oxygen species (ROS) production, and mitochondrial protein content. In addition, mitochondrial acetylation status and SIRT protein content was determined. The OVX group exhibited increased ROS production compared to the SHAM group. However, no differences were detected in oxygen consumption, mitochondrial protein content, acetylation status, or total SIRT content between groups. The data shows that ovariectomy increases mitochondrial ROS production, which suggests a novel mechanism to consider.en_US
dc.identifier.urihttp://hdl.handle.net/1903/13012
dc.subject.pqcontrolledPhysiologyen_US
dc.subject.pqcontrolledHealth sciencesen_US
dc.subject.pqcontrolledCellular biologyen_US
dc.subject.pquncontrolledfatty liveren_US
dc.subject.pquncontrolledHepatic steatosisen_US
dc.subject.pquncontrolledmitochondriaen_US
dc.subject.pquncontrolledovariectomyen_US
dc.subject.pquncontrolledreactive oxygen speciesen_US
dc.titleAssociation between increased hepatic lipid storage and impaired hepatic mitochondrial function in ovariectomized miceen_US
dc.typeThesisen_US

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