Fitness of the transgenic malaria-refractory mosquito Anopheles gambiae

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dc.contributor.advisorHawthorne, David Jen_US
dc.contributor.authorLadner, Deborah Tillmanen_US
dc.contributor.departmentEntomologyen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2005-02-02T06:25:09Z
dc.date.available2005-02-02T06:25:09Z
dc.date.issued2004-11-11en_US
dc.description.abstractThe African mosquito Anopheles gambiae is the insect vector responsible for half of worldwide malaria infections. One option for reducing malaria is genetic manipulation of the vector. By creating transgenic mosquitoes incapable of spreading the malaria pathogen, the human-mosquito-human cycle of infection may be interrupted. In order for the engineered Plasmodium-refractory mosquitoes to be effective they need to be able to thrive in nature and to compete successfully with nontransformed conspecifics. Two lines of transgenic An. gambiae were used in this study to evaluate the fitness consequences of transgenesis in this insect. Life table characteristics of two transformed An. gambiae lines were compared to a control line to determine if fitness costs were present. Specific traits measures between transgenic and control mosquitoes were not significantly different, and the transgenic lines had no evidence of position effects.en_US
dc.format.extent671868 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.urihttp://hdl.handle.net/1903/1991
dc.language.isoen_US
dc.subject.pqcontrolledBiology, Entomologyen_US
dc.subject.pquncontrolledAn. gambiaeen_US
dc.subject.pquncontrolledmalariaen_US
dc.subject.pquncontrolledtransgenicen_US
dc.subject.pquncontrolledlife tableen_US
dc.subject.pquncontrolledfitnessen_US
dc.titleFitness of the transgenic malaria-refractory mosquito Anopheles gambiaeen_US
dc.typeThesisen_US

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