Automated eukaryotic gene structure annotation using EVidenceModeler and the Program to Assemble Spliced Alignments

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dc.contributor.authorHaas, Brian U.
dc.contributor.authorSalzberg, Steven L.
dc.contributor.authorZhu, Wei
dc.contributor.authorPertea, Mihaela
dc.contributor.authorAllen, Jonathan E.
dc.contributor.authorOrvis, Joshua
dc.contributor.authorWhite, Owen
dc.contributor.authorBuell, C Robin
dc.contributor.authorWortman, Jennifer R
dc.date.accessioned2008-06-10T18:58:16Z
dc.date.available2008-06-10T18:58:16Z
dc.date.issued2008-01
dc.description.abstractEVidenceModeler (EVM) is presented as an automated eukaryotic gene structure annotation tool that reports eukaryotic gene structures as a weighted consensus of all available evidence. EVM, when combined with the Program to Assemble Spliced Alignments (PASA), yields a comprehensive, configurable annotation system that predicts protein-coding genes and alternatively spliced isoforms. Our experiments on both rice and human genome sequences demonstrate that EVM produces automated gene structure annotation approaching the quality of manual curation.en
dc.description.urihttps://doi.org/10.1186/gb-2008-9-1-r7
dc.format.extent739337 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citationHaas, B.J., Salzberg, S.L., Zhu, W. et al. Automated eukaryotic gene structure annotation using EVidenceModeler and the Program to Assemble Spliced Alignments. Genome Biol 9, R7 (2008).en
dc.identifier.urihttp://hdl.handle.net/1903/7992
dc.language.isoen_USen
dc.publisherGenome Biologyen
dc.relation.isAvailableAtCollege of Computer, Mathematical & Physical Sciencesen_us
dc.relation.isAvailableAtComputer Scienceen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectEVidenceModeler (EVM)en
dc.subjectautomated eukaryotic gene structure annotation toolen
dc.subjectProgram to Assemble Spliced Alignments (PASA)en
dc.subjectmanual curationen
dc.titleAutomated eukaryotic gene structure annotation using EVidenceModeler and the Program to Assemble Spliced Alignmentsen
dc.typeArticleen

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