The Role of Interleukin-19 in Interleukin-10 Production by Regulatory Macrophages

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dc.contributor.advisorMosser, David M.en_US
dc.contributor.authorYahil, Ron Jonathanen_US
dc.contributor.departmentCell Biology & Molecular Geneticsen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2010-07-02T06:04:43Z
dc.date.available2010-07-02T06:04:43Z
dc.date.issued2010en_US
dc.description.abstractInterleukin-19 (IL-19) is a recently discovered member of the IL-10 family of Class II cytokines. Although it is known to be secreted by monocytes and has been associated with various models of disease, the biological function of IL-19 remains largely unknown. IL-19 does share many important characteristics with IL-10. Because of this, we hypothesized that IL-19 may be regulated in a manner similar to IL-10, and may provide insight into the molecular mechanism of IL-10 regulation. In addition, IL-19 has been reported to increase IL-10 production in monocytes, and we theorized that it may be able to do the same in macrophages. Like IL-10, IL-19 is expressed in regulatory macrophages. Also, IL-19 is itself able to increase IL-10 production in regulatory macrophages, and the mechanism is independent of ERK phosphorylation. This work suggests that IL-19 can play a central role in the anti-inflammatory processes of IL-10.en_US
dc.identifier.urihttp://hdl.handle.net/1903/10384
dc.subject.pqcontrolledHealth Sciences, Immunologyen_US
dc.subject.pqcontrolledBiology, Molecularen_US
dc.subject.pqcontrolledBiology, Cellen_US
dc.subject.pquncontrolledCytokinesen_US
dc.subject.pquncontrolledInflammationen_US
dc.subject.pquncontrolledInterleukin-10en_US
dc.subject.pquncontrolledInterleukin-19en_US
dc.subject.pquncontrolledMacrophageen_US
dc.subject.pquncontrolledMAP kinaseen_US
dc.titleThe Role of Interleukin-19 in Interleukin-10 Production by Regulatory Macrophagesen_US
dc.typeThesisen_US

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