A Pro-Drug Approach for Selective Modulation of AI-2-Mediated Bacterial Cell-to-Cell Communication

dc.contributor.authorGuo, Min
dc.contributor.authorGamby, Sonja
dc.contributor.authorNakayama, Shizuka
dc.contributor.authorSmith, Jacqueline
dc.contributor.authorSintim, Herman O.
dc.date.accessioned2024-01-30T18:57:43Z
dc.date.available2024-01-30T18:57:43Z
dc.date.issued2012-03-21
dc.description.abstractThe universal quorum sensing autoinducer, AI-2, is utilized by several bacteria. Analogs of AI-2 have the potential to modulate bacterial behavior. Selectively quenching the communication of a few bacteria, in the presence of several others in an ecosystem, using analogs of AI-2 is non-trivial due to the ubiquity of AI-2 processing receptors in many bacteria that co-exist. Herein, we demonstrate that when an AI-2 analog, isobutyl DPD (which has been previously shown to be a quorum sensing, QS, quencher in both Escherichia coli and Salmonella typhimurium) is modified with ester groups, which get hydrolyzed once inside the bacterial cells, only QS in E. coli, but not in S. typhimurium, is inhibited. The origin of this differential QS inhibition could be due to differences in analog permeation of the bacterial membranes or ester hydrolysis rates. Such differences could be utilized to selectively target QS in specific bacteria amongst a consortium of other species that also use AI-2 signaling.
dc.description.urihttps://doi.org/10.3390/s120303762
dc.identifierhttps://doi.org/10.13016/dspace/0cym-udtz
dc.identifier.citationGuo, M.; Gamby, S.; Nakayama, S.; Smith, J.; Sintim, H.O. A Pro-Drug Approach for Selective Modulation of AI-2-Mediated Bacterial Cell-to-Cell Communication. Sensors 2012, 12, 3762-3772.
dc.identifier.urihttp://hdl.handle.net/1903/31625
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtChemistry & Biochemistryen_us
dc.relation.isAvailableAtCollege of Computer, Mathematical & Natural Sciencesen_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectAI-2
dc.subjectDPD analog
dc.subjectquorum sensing inhibitor
dc.subjectester pro-drug
dc.subjectIsr expression
dc.subjectautoinducer cell permeation
dc.subjectautoinducer processing
dc.subjectenteric bacteria
dc.titleA Pro-Drug Approach for Selective Modulation of AI-2-Mediated Bacterial Cell-to-Cell Communication
dc.typeArticle
local.equitableAccessSubmissionNo

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