Small Molecule Inhibitors of AI-2 Signaling in Bacteria: State-of-the-Art and Future Perspectives for Anti-Quorum Sensing Agents

dc.contributor.authorGuo, Min
dc.contributor.authorGamby, Sonja
dc.contributor.authorZheng, Yue
dc.contributor.authorSintim, Herman O.
dc.date.accessioned2024-01-30T16:59:32Z
dc.date.available2024-01-30T16:59:32Z
dc.date.issued2013-08-29
dc.description.abstractBacteria respond to different small molecules that are produced by other neighboring bacteria. These molecules, called autoinducers, are classified as intraspecies (i.e., molecules produced and perceived by the same bacterial species) or interspecies (molecules that are produced and sensed between different bacterial species). AI-2 has been proposed as an interspecies autoinducer and has been shown to regulate different bacterial physiology as well as affect virulence factor production and biofilm formation in some bacteria, including bacteria of clinical relevance. Several groups have embarked on the development of small molecules that could be used to perturb AI-2 signaling in bacteria, with the ultimate goal that these molecules could be used to inhibit bacterial virulence and biofilm formation. Additionally, these molecules have the potential to be used in synthetic biology applications whereby these small molecules are used as inputs to switch on and off AI-2 receptors. In this review, we highlight the state-of-the-art in the development of small molecules that perturb AI-2 signaling in bacteria and offer our perspective on the future development and applications of these classes of molecules.
dc.description.urihttps://doi.org/10.3390/ijms140917694
dc.identifierhttps://doi.org/10.13016/dspace/eaxe-wczv
dc.identifier.citationGuo, M.; Gamby, S.; Zheng, Y.; Sintim, H.O. Small Molecule Inhibitors of AI-2 Signaling in Bacteria: State-of-the-Art and Future Perspectives for Anti-Quorum Sensing Agents. Int. J. Mol. Sci. 2013, 14, 17694-17728.
dc.identifier.urihttp://hdl.handle.net/1903/31609
dc.language.isoen_US
dc.publisherMDPI
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtChemistry & Biochemistryen_us
dc.relation.isAvailableAtCollege of Computer, Mathematical & Natural Sciencesen_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectquorum sensing
dc.subjectvirulence
dc.subjectbiofilm formation
dc.subjectbacteria
dc.subjectautoinducer
dc.subjectantagonists
dc.subjectAI-2
dc.titleSmall Molecule Inhibitors of AI-2 Signaling in Bacteria: State-of-the-Art and Future Perspectives for Anti-Quorum Sensing Agents
dc.typeArticle
local.equitableAccessSubmissionNo

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