Properties of a Gallium-Conjugated Siderophore Complex as an Antibacterial Treatment

dc.contributor.advisorWoodard, Ben
dc.contributor.authorCendo, Demetri Z.
dc.contributor.authorEnkeshafi, Parmida
dc.contributor.authorHan, Paul W.
dc.contributor.authorHarner, Cameron R.
dc.contributor.authorHerman, Rae J.
dc.contributor.authorHuffman, Margo P.
dc.contributor.authorLee, Faith C.
dc.contributor.authorLiu, Qing T.
dc.contributor.authorNguyen, Connie P.
dc.date.accessioned2018-06-22T17:39:50Z
dc.date.available2018-06-22T17:39:50Z
dc.date.issued2018
dc.description.abstractIn 2013, the Centers for Disease Control and Prevention estimated that approximately two million individuals in the United States developed antibiotic-resistant infections. This increasing rate of bacterial antibiotic resistance necessitates the development of alternative treatments. Gallium-desferrioxamine (Ga-DFO), a gallium-chelated bacterial siderophore, offers a promising alternative treatment by exploiting the natural iron-uptake pathway of bacteria to introduce toxic gallium ions into the cytoplasm. Previous research demonstrates that the Ga-DFO complex is effective against a number of bacterial strains in ideal treatment conditions. The present study examines the properties of Ga-DFO and its effectiveness against additional strains in a non-iron-depleted environment and in mammalian cell culture. Ga-DFO was found to successfully inhibit the growth of each bacterial strain tested. It was also effective when added at any time point during bacterial growth.en_US
dc.identifierhttps://doi.org/10.13016/M23B5WB7J
dc.identifier.urihttp://hdl.handle.net/1903/20673
dc.language.isoen_USen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)
dc.subjectGemstone Team GOLDen_US
dc.titleProperties of a Gallium-Conjugated Siderophore Complex as an Antibacterial Treatmenten_US
dc.typeThesisen_US

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