Detection and correction of false segmental duplications caused by genome mis-assembly
| dc.contributor.author | Kelley, David R | |
| dc.contributor.author | Salzberg, Steven L | |
| dc.date.accessioned | 2013-01-10T21:31:09Z | |
| dc.date.available | 2013-01-10T21:31:09Z | |
| dc.date.issued | 2010-03-10 | |
| dc.description.abstract | Diploid genomes with divergent chromosomes present special problems for assembly software as two copies of especially polymorphic regions may be mistakenly constructed, creating the appearance of a recent segmental duplication. We developed a method for identifying such false duplications and applied it to four vertebrate genomes. For each genome, we corrected mis-assemblies, improved estimates of the amount of duplicated sequence, and recovered polymorphisms between the sequenced chromosomes. | en_US |
| dc.description.uri | https://doi.org/10.1186/gb-2010-11-3-r28 | |
| dc.identifier.citation | Kelley, D.R., Salzberg, S.L. Detection and correction of false segmental duplications caused by genome mis-assembly. Genome Biol 11, R28 (2010). | en_US |
| dc.identifier.uri | http://hdl.handle.net/1903/13375 | |
| dc.language.iso | en_US | en_US |
| dc.relation.isAvailableAt | College of Computer, Mathematical & Physical Sciences | en_us |
| dc.relation.isAvailableAt | Digital Repository at the University of Maryland | en_us |
| dc.relation.isAvailableAt | Biology | en_us |
| dc.relation.isAvailableAt | University of Maryland (College Park, MD) | en_us |
| dc.subject | genome mis-assembly | en_US |
| dc.subject | false duplications | en_US |
| dc.title | Detection and correction of false segmental duplications caused by genome mis-assembly | en_US |
| dc.type | Article | en_US |