Detection and correction of false segmental  duplications caused by genome mis-assembly

dc.contributor.author	Kelley, David R
dc.contributor.author	Salzberg, Steven L
dc.date.accessioned	2013-01-10T21:31:09Z
dc.date.available	2013-01-10T21:31:09Z
dc.date.issued	2010-03-10
dc.description.abstract	Diploid genomes with divergent chromosomes present special problems for assembly software as two copies of especially polymorphic regions may be mistakenly constructed, creating the appearance of a recent segmental duplication. We developed a method for identifying such false duplications and applied it to four vertebrate genomes. For each genome, we corrected mis-assemblies, improved estimates of the amount of duplicated sequence, and recovered polymorphisms between the sequenced chromosomes.	en_US
dc.description.uri	https://doi.org/10.1186/gb-2010-11-3-r28
dc.identifier.citation	Kelley, D.R., Salzberg, S.L. Detection and correction of false segmental duplications caused by genome mis-assembly. Genome Biol 11, R28 (2010).	en_US
dc.identifier.uri	http://hdl.handle.net/1903/13375
dc.language.iso	en_US	en_US
dc.relation.isAvailableAt	College of Computer, Mathematical & Physical Sciences	en_us
dc.relation.isAvailableAt	Digital Repository at the University of Maryland	en_us
dc.relation.isAvailableAt	Biology	en_us
dc.relation.isAvailableAt	University of Maryland (College Park, MD)	en_us
dc.subject	genome mis-assembly	en_US
dc.subject	false duplications	en_US
dc.title	Detection and correction of false segmental duplications caused by genome mis-assembly	en_US
dc.type	Article	en_US

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