HIPPOCAMPAL SUBREGION VOLUME IN HIGH-RISK OFFSPRING PREDICTS INCREASES IN DEPRESSIVE SYMPTOMS ACROSS THE TRANSITION TO ADOLESCENCE

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dc.contributor.advisorDougherty, Lea R.en_US
dc.contributor.authorHubachek, Samantha Qirkoen_US
dc.contributor.departmentPsychologyen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2021-02-14T06:32:37Z
dc.date.available2021-02-14T06:32:37Z
dc.date.issued2020en_US
dc.description.abstractThe hippocampus has been implicated in the pathophysiology of depression. This study examined whether youth hippocampal subregion volumes were differentially associated with maternal depression history and youth’s depressive symptoms across the transition to adolescence. 74 preadolescent offspring (Mage=10.74+/-.84 years) of mothers with (n=33) and without a lifetime depression history (n=41) completed a structural brain scan. Youth depressive symptoms were assessed prior to the neuroimaging assessment at age 9 (Mage=9.08+/-.29 years), at the neuroimaging assessment, and in early adolescence (Mage=12.56+/-.40 years). Maternal depression was associated with preadolescent offspring’s reduced bilateral hippocampal head volumes and increased left hippocampal body volume. Reduced bilateral head volumes were associated with offspring’s increased concurrent depressive symptoms. Furthermore, reduced right hippocampal head volume mediated associations between maternal depression and increases in offspring depressive symptoms from age 9 to age 12. Findings implicate reductions in hippocampal head volume in the intergenerational transmission of risk from parents to offspring.en_US
dc.identifierhttps://doi.org/10.13016/blro-xzbp
dc.identifier.urihttp://hdl.handle.net/1903/26793
dc.language.isoenen_US
dc.subject.pqcontrolledPsychologyen_US
dc.subject.pquncontrolledadolescenceen_US
dc.subject.pquncontrolleddepressionen_US
dc.subject.pquncontrolledhippocampusen_US
dc.subject.pquncontrolledmaternal depressionen_US
dc.subject.pquncontrolledMRIen_US
dc.subject.pquncontrolledvolumeen_US
dc.titleHIPPOCAMPAL SUBREGION VOLUME IN HIGH-RISK OFFSPRING PREDICTS INCREASES IN DEPRESSIVE SYMPTOMS ACROSS THE TRANSITION TO ADOLESCENCEen_US
dc.typeThesisen_US

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