VISUALIZATION OF CERAMIDE CHANNELS BY TRANSMISSION ELECTRON MICROSCOPY

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dc.contributor.advisorCOLOMBINI, MARCOen_US
dc.contributor.authorSAMANTA, SOUMYAen_US
dc.contributor.departmentBiologyen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2011-07-07T05:53:15Z
dc.date.available2011-07-07T05:53:15Z
dc.date.issued2011en_US
dc.description.abstractFunctional studies have shown that the sphingolipid ceramide, self-assembles in phospholipid membranes to form large channels capable of allowing proteins to cross the membrane. Here these channels are visualized by negative stain transmission electron microscopy. The images contain features consistent with stain-filled pores having a roughly circular profile. There is no indication of tilt, and the results are consistent with the formation of right cylinders. The sizes of the pores range from 5 to 40 nm in diameter with an asymmetric distribution indicating no apparent upper size limit. The size distribution matches well with the distribution of sizes calculated from electrophysiological measurements.en_US
dc.identifier.urihttp://hdl.handle.net/1903/11734
dc.subject.pqcontrolledBiophysicsen_US
dc.subject.pqcontrolledBiochemistryen_US
dc.subject.pqcontrolledBiologyen_US
dc.subject.pquncontrolledApoptosisen_US
dc.subject.pquncontrolledCeramideen_US
dc.subject.pquncontrolledChannelen_US
dc.subject.pquncontrolledMitochondriaen_US
dc.subject.pquncontrolledProgrammed Cell Deathen_US
dc.subject.pquncontrolledTransmission Electron Microscopyen_US
dc.titleVISUALIZATION OF CERAMIDE CHANNELS BY TRANSMISSION ELECTRON MICROSCOPYen_US
dc.typeThesisen_US

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