The effect of collagen organization on tensile strength loss in anterior cruciate ligament grafts post-reconstruction surgery

Simple item page
dc.contributor.advisorHsieh, Adam
dc.contributor.advisorKim, Hyunchul
dc.contributor.authorChandramani, Ayushi
dc.contributor.authorCostales, Matthew G.
dc.contributor.authorGarbus, Benjamin C.
dc.contributor.authorHartstein, Joseph D.
dc.contributor.authorHeffner, Kelley M.
dc.contributor.authorJain, Rupal S.
dc.contributor.authorKlein, Kelly M.
dc.contributor.authorMcDonnell, Alicia N.
dc.contributor.authorPatel, Payal V.
dc.contributor.authorStefanelli, Victoria L.
dc.contributor.authorWang, Jenny
dc.contributor.authorWeinberg, Joseph T.
dc.contributor.authorZhang, Tina
dc.date.accessioned2012-05-17T19:55:46Z
dc.date.available2012-05-17T19:55:46Z
dc.date.issued2012
dc.descriptionGemstone Team LEGSen_US
dc.description.abstractGrafts used for anterior cruciate ligament (ACL) reconstructions fall short of restoring native mechanics. This study investigated a morphological cause for tension loss by comparing native ACL and two common grafts, bone-patellar tendonbone (BPTB) and semitendinosus/gracilis hamstring tendon (ST/G), in a cadaveric system. Tension loss during continuous passive motion was quantified via force transducer. Microstructural changes were assessed by measuring collagen crimp angles. No significant differences were found for rates of percent tension loss relative to total tension loss among grafts. However, all groups displayed exponential decay, implying rapid tension loss. The crimp angles for the unstressed grafts were significantly different from each other, suggesting innate differences. The percent change experienced by stressed grafts, normalized to their unstressed baselines, showed that ST’s crimp behavior was significantly different from that of ACL and BPTB, implying the BPTB graft is superior for ACL reconstruction because it better mimics the ACL’s morphological behavior.en_US
dc.identifier.urihttp://hdl.handle.net/1903/12494
dc.language.isoen_USen_US
dc.relation.isAvailableAtDigital Repository at the University of Maryland
dc.relation.isAvailableAtGemstone Program, University of Maryland (College Park, Md)
dc.subjectACL reconstructionen_US
dc.subjectanterior cruciate ligamenten_US
dc.subjectgraftsen_US
dc.subjectsurgeryen_US
dc.subjecttensionen_US
dc.subjectcollagenen_US
dc.subjectGemstone Team LEGSen_US
dc.titleThe effect of collagen organization on tensile strength loss in anterior cruciate ligament grafts post-reconstruction surgeryen_US
dc.typeThesisen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
LEGS.pdf
Size:
44.42 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 2 of 2
No Thumbnail Available
Name:
license.txt
Size:
1.57 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
No Thumbnail Available
Name:
LEGS_DRUM.pdf
Size:
65.97 KB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Gemstone Team Research