NIBIB is less than one year old. It has begun the process of building the new Institute and identifying key principles to guide its growth. The Institute is not focused on specific health conditions associated with life-span, disease, or anatomical site. It is, however, uniquely positioned to identify challenges in medical research that can benefit from bioengineering and bioimaging approaches, facilitate cooperation, and promote transdisciplinary research training. NIBIB seeks to provide leadership in developing cross-cutting research and training in biomedical imaging and bioengineering, fostered by strong partnerships and collaborations, with the ultimate goal of improving the health and well-being of all Americans.