A Genome Scan for Hypertension Susceptibility Loci in Populations of Chinese and Japanese Origins

Abstract

Background: Our understanding of genes that predispose to essential hypertension is poor. Methods: A genome-wide scan for linkage at ~10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low–normal blood pressure (BP) (N = 184), or discordant for BP (N = 580). Results: There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5. Conclusions: We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population.