A Genome Scan for Hypertension Susceptibility Loci in Populations of Chinese and Japanese Origins

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dc.contributor.authorRanade, Koustubh
dc.contributor.authorHinds, David
dc.contributor.authorHsiung, Chao Agnes
dc.contributor.authorChuang, Lee-Ming
dc.contributor.authorChang, Mau-Song
dc.contributor.authorChen, Ying-Tsung
dc.contributor.authorPesich, Robert
dc.contributor.authorHebert, Joan
dc.contributor.authorChen, Yii-Der I
dc.contributor.authorDzau, Victor
dc.contributor.authorOlshen, Richard
dc.contributor.authorCurb, David
dc.contributor.authorBotstein, David
dc.contributor.authorCox, David R
dc.contributor.authorRisch, Neil
dc.date.accessioned2019-08-14T14:58:24Z
dc.date.available2019-08-14T14:58:24Z
dc.date.issued2003
dc.description.abstractBackground: Our understanding of genes that predispose to essential hypertension is poor. Methods: A genome-wide scan for linkage at ~10 cM resolution was done on 1425 sibpairs of Chinese and Japanese origins that were concordant for hypertension (N = 661), low–normal blood pressure (BP) (N = 184), or discordant for BP (N = 580). Results: There was no significant evidence of linkage to a single locus in the genome. There was suggestive evidence of linkage to chromosome 10p, with a LOD score of 2.5. Conclusions: We can exclude the possibility that a single gene accounts for at least 15% of the variance in hypertension in this population.
dc.description.urihttp://www.nature.com/ajh/journal/v16/n2/full/ajh200334a.html
dc.identifierhttps://doi.org/10.13016/rnct-fek6
dc.identifier.citationRanade, Koustubh and Hinds, David and Hsiung, Chao Agnes and Chuang, Lee-Ming and Chang, Mau-Song and Chen, Ying-Tsung and Pesich, Robert and Hebert, Joan and Chen, Yii-Der I and Dzau, Victor and Olshen, Richard and Curb, David and Botstein, David and Cox, David R and Risch, Neil (2003) A Genome Scan for Hypertension Susceptibility Loci in Populations of Chinese and Japanese Origins. American Journal of Hypertension, 16. pp. 158-162.
dc.identifier.otherEprint ID 162
dc.identifier.urihttp://hdl.handle.net/1903/22352
dc.subjectPublic Health
dc.subjectHypertension
dc.subjectResearch
dc.subjectGenetics and Race
dc.subjecthypertension
dc.subjectgenetics
dc.subjectlinkage
dc.titleA Genome Scan for Hypertension Susceptibility Loci in Populations of Chinese and Japanese Origins
dc.typeArticle

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