Genome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional chinese medicine

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dc.contributor.authorZheng, Peng
dc.contributor.authorXia, Yongliang
dc.contributor.authorXiao, Guohua
dc.contributor.authorXiong, Chenghui
dc.contributor.authorHu, Xiao
dc.contributor.authorZhang, Siwei
dc.contributor.authorZheng, Huajun
dc.contributor.authorHuang, Yin
dc.contributor.authorZhou, Yan
dc.contributor.authorWang, Shengyue
dc.contributor.authorZhao, Guo-Ping
dc.contributor.authorLiu, Xingzhong
dc.contributor.authorSt Leger, Raymond J
dc.contributor.authorWang, Chengshu
dc.date.accessioned2021-11-01T19:34:41Z
dc.date.available2021-11-01T19:34:41Z
dc.date.issued2011-11-23
dc.description.abstractSpecies in the ascomycete fungal genus Cordyceps have been proposed to be the teleomorphs of Metarhizium species. The latter have been widely used as insect biocontrol agents. Cordyceps species are highly prized for use in traditional Chinese medicines, but the genes responsible for biosynthesis of bioactive components, insect pathogenicity and the control of sexuality and fruiting have not been determined. Here, we report the genome sequence of the type species Cordyceps militaris. Phylogenomic analysis suggests that different species in the Cordyceps/Metarhizium genera have evolved into insect pathogens independently of each other, and that their similar large secretomes and gene family expansions are due to convergent evolution. However, relative to other fungi, including Metarhizium spp., many protein families are reduced in C. militaris, which suggests a more restricted ecology. Consistent with its long track record of safe usage as a medicine, the Cordyceps genome does not contain genes for known human mycotoxins. We establish that C. militaris is sexually heterothallic but, very unusually, fruiting can occur without an opposite mating-type partner. Transcriptional profiling indicates that fruiting involves induction of the Zn2Cys6-type transcription factors and MAPK pathway; unlike other fungi, however, the PKA pathway is not activated.en_US
dc.description.urihttps://doi.org/10.1186/gb-2011-12-11-r116
dc.identifierhttps://doi.org/10.13016/wmq5-us5d
dc.identifier.citationZheng, P., Xia, Y., Xiao, G. et al. Genome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional chinese medicine. Genome Biol 12, R116 (2012).en_US
dc.identifier.urihttp://hdl.handle.net/1903/28080
dc.language.isoen_USen_US
dc.publisherSpringer Natureen_US
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtEntomologyen_us
dc.relation.isAvailableAtCollege of Computer, Mathematical & Natural Sciencesen_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us
dc.subjectFruiting Bodyen_US
dc.subjectGraminearumen_US
dc.subjectTrichotheceneen_US
dc.subjectErgot Alkaloiden_US
dc.subjectPatulinen_US
dc.titleGenome sequence of the insect pathogenic fungus Cordyceps militaris, a valued traditional chinese medicineen_US
dc.typeArticleen_US

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