Microarray analysis of Pseudomonas aeruginosa reveals induction of pyocin genes in response to hydrogen peroxide
| dc.contributor.author | Chang, Wook | |
| dc.contributor.author | Small, David A | |
| dc.contributor.author | Toghrol, Freshteh | |
| dc.contributor.author | Bentley, William E | |
| dc.date.accessioned | 2021-12-09T15:31:48Z | |
| dc.date.available | 2021-12-09T15:31:48Z | |
| dc.date.issued | 2005-09-08 | |
| dc.description.abstract | Pseudomonas aeruginosa, a pathogen infecting those with cystic fibrosis, encounters toxicity from phagocyte-derived reactive oxidants including hydrogen peroxide during active infection. P. aeruginosa responds with adaptive and protective strategies against these toxic species to effectively infect humans. Despite advances in our understanding of the responses to oxidative stress in many specific cases, the connectivity between targeted protective genes and the rest of cell metabolism remains obscure. Pseudomonas aeruginosa, a pathogen infecting those with cystic fibrosis, encounters toxicity from phagocyte-derived reactive oxidants including hydrogen peroxide during active infection. P. aeruginosa responds with adaptive and protective strategies against these toxic species to effectively infect humans. Despite advances in our understanding of the responses to oxidative stress in many specific cases, the connectivity between targeted protective genes and the rest of cell metabolism remains obscure. This finding proposes that pyocin production might be another novel defensive scheme against oxidative attack by host cells. | en_US |
| dc.description.uri | https://doi.org/10.1186/1471-2164-6-115 | |
| dc.identifier | https://doi.org/10.13016/snua-pfx5 | |
| dc.identifier.citation | Chang, W., Small, D.A., Toghrol, F. et al. Microarray analysis of Pseudomonas aeruginosa reveals induction of pyocin genes in response to hydrogen peroxide. BMC Genomics 6, 115 (2005). | en_US |
| dc.identifier.uri | http://hdl.handle.net/1903/28224 | |
| dc.language.iso | en_US | en_US |
| dc.publisher | Springer Nature | en_US |
| dc.relation.isAvailableAt | College of Computer, Mathematical & Physical Sciences | en_us |
| dc.relation.isAvailableAt | Digital Repository at the University of Maryland | en_us |
| dc.relation.isAvailableAt | Biology | en_us |
| dc.relation.isAvailableAt | University of Maryland (College Park, MD) | en_us |
| dc.subject | Intracellular Iron | en_US |
| dc.subject | Immunity Protein | en_US |
| dc.subject | GeneChip Array | en_US |
| dc.subject | Iron Regulation | en_US |
| dc.subject | Siderophore Receptor | en_US |
| dc.title | Microarray analysis of Pseudomonas aeruginosa reveals induction of pyocin genes in response to hydrogen peroxide | en_US |
| dc.type | Article | en_US |