In Vitro Study of an Orange Oil Derived Alternative to Antibiotics in the Treatment of Bovine Mastitis

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dc.contributor.advisorBiswas, Debabrataen_US
dc.contributor.authorFederman, Cassandra Skyeen_US
dc.contributor.departmentAnimal Sciencesen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.date.accessioned2016-02-09T06:36:43Z
dc.date.available2016-02-09T06:36:43Z
dc.date.issued2015en_US
dc.description.abstractBovine mastitis is a costly disease in the U.S. dairy industry. Its major causative agent Staphylococcus aureus is often unresponsive to antibiotic therapy. Our first study examined terpeneless, cold-pressed Valencia (CPV) orange oil as a possible alternative to antibiotic therapy in the treatment of S. aureus associated bovine mastitis. Orange oil showed significant inhibition of S. aureus growth and invasion of bovine epithelial mammary cells, but only modest reductions in pre-formed biofilms, which contribute to persistence of S. aureus infections. Our second study examined major components of terpeneless, CPV orange oil. Of four major compounds tested, only citral and linalool had significant inhibitory effects on S. aureus growth. In addition, they were capable of reducing pre-formed biofilms as well as association and invasion to bovine epithelial mammary cells. Part of this inhibition was due to downregulation of virulence and biofilm genes.en_US
dc.identifierhttps://doi.org/10.13016/M2Q72B
dc.identifier.urihttp://hdl.handle.net/1903/17387
dc.language.isoenen_US
dc.subject.pqcontrolledMicrobiologyen_US
dc.subject.pqcontrolledAnimal diseasesen_US
dc.subject.pqcontrolledAnimal sciencesen_US
dc.subject.pquncontrolledcattleen_US
dc.subject.pquncontrolleddairyen_US
dc.subject.pquncontrolledmastitisen_US
dc.subject.pquncontrolledorange oilen_US
dc.subject.pquncontrolledStaphylococcus aureusen_US
dc.titleIn Vitro Study of an Orange Oil Derived Alternative to Antibiotics in the Treatment of Bovine Mastitisen_US
dc.typeThesisen_US

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