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    Antioxidant and Anti-proliferative properties of selected grape seed extracts

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    No. of downloads: 2842

    Date
    2009
    Author
    Bloom, Raquel Zorah
    Advisor
    Yu, Liangli
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    Abstract
    This study examined chardonnay, muscadine, concord, and ruby red grape seed oil and flour extracts for antioxidant and anti-proliferative properties. The extracts were tested for total phenolic content, DPPH* · and ABTS*+ ·radical scavenging capacity and effect against HT-29 cancer cell proliferation. All of the grape seed extracts exhibited ABTS*+ · and DPPH*· radical quenching activity. The flour extracts from chardonnay demonstrated the highest ABTS*+· radical quenching capacity of 186 μμmoles trolox equivalents/g and DPPH* · radical quenching activity of 30 μμmoles trolox equivalents/g. All of the grape seed oil and flour extracts contained significant levels of phenolics. Chardonnay grape seed flour extract displayed the most prominent dose dependent anti-proliferative effect. Muscadine and ruby red, but not concord grape seed flour extracts, also exhibited anti-proliferative activities. The collected data advocate for the potential of grape seed extracts as dietary sources of anti-proliferative and antioxidant components.
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    http://hdl.handle.net/1903/9329
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    • Nutrition & Food Science Theses and Dissertations
    • UMD Theses and Dissertations

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