Now showing items 1-5 of 10

    • Protein-based vehicles for biomimetic RNAi delivery 

      Pottash, Alex Eli; Kuffner, Christopher; Noonan-Shueh, Madeleine; Jay, Steven M. (BioMed Central, 2019-02-26)
      Broad translational success of RNA interference (RNAi) technology depends on the development of effective delivery approaches. To that end, researchers have developed a variety of strategies, including chemical modification ...
    • Gelatin-Enabled Microsensor for Pancreatic Trypsin Sensing 

      Banis, George; Beardslee, Luke A.; Ghodssi, Reza (MDPI, 2018-01-31)
      Digestive health is critically dependent on the secretion of enzymes from the exocrine pancreas to the duodenum via the pancreatic duct. Specifically, pancreatic trypsin is a major protease responsible for breaking down ...
    • Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance 

      Wang, Hai; Gao, Zan; Liu, Xuanyou; Agarwal, Pranay; Zhao, Shuting; Conroy, Daniel W.; Ji, Guang; Yu, Jianhua; Jaroniec, Christopher P.; Liu, Zhenguo; Lu, Xiongbin; Li, Xiaodong; He, Xiaoming (Nature Publishing Group, 2018-02-08)
      Multidrug resistance is a major challenge to cancer chemotherapy. The multidrug resistance phenotype is associated with the overexpression of the adenosine triphosphate (ATP)-driven transmembrane efflux pumps in cancer ...
    • The Binding Effect of Proteins on Medications and Its Impact on Electrochemical Sensing: Antipsychotic Clozapine as a Case Study 

      Banis, George E.; Winkler, Thomas; Barton, Patricia; Chocron, Sheryl E.; Kim, Eunkyoung; Kelly, Deanna L.; Payne, Gregory F.; Ben-Yoav, Hadar; Ghodssi, Reza (Multidisciplinary Digital Publishing Institute (MDPI), 2017-08-01)
      Clozapine (CLZ), a dibenzodiazepine, is demonstrated as the optimal antipsychotic for patients suffering from treatment-resistant schizophrenia. Like many other drugs, understanding the concentration of CLZ in a patient’s ...
    • Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific 

      Tostanoski, Lisa H.; Chiu, Yu-Chieh; Gammon, Joshua M.; Simon, Thomas; Andorko, James I.; Bromberg, Jonathan S.; Jewell, Christopher M. (Cell Press, 2016-09-13)
      Many experimental therapies for autoimmune diseases, such as multiple sclerosis (MS), aim to bias T cells toward tolerogenic phenotypes without broad suppression. However, the link between local signal integration in lymph ...