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  • Gelatin-Enabled Microsensor for Pancreatic Trypsin Sensing 

    Banis, George; Beardslee, Luke A.; Ghodssi, Reza (MDPI, 2018-01-31)
    Digestive health is critically dependent on the secretion of enzymes from the exocrine pancreas to the duodenum via the pancreatic duct. Specifically, pancreatic trypsin is a major protease responsible for breaking down ...
  • Targeted production of reactive oxygen species in mitochondria to overcome cancer drug resistance 

    Wang, Hai; Gao, Zan; Liu, Xuanyou; Agarwal, Pranay; Zhao, Shuting; Conroy, Daniel W.; Ji, Guang; Yu, Jianhua; Jaroniec, Christopher P.; Liu, Zhenguo; Lu, Xiongbin; Li, Xiaodong; He, Xiaoming (Nature Publishing Group, 2018-02-08)
    Multidrug resistance is a major challenge to cancer chemotherapy. The multidrug resistance phenotype is associated with the overexpression of the adenosine triphosphate (ATP)-driven transmembrane efflux pumps in cancer ...
  • The Binding Effect of Proteins on Medications and Its Impact on Electrochemical Sensing: Antipsychotic Clozapine as a Case Study 

    Banis, George E.; Winkler, Thomas; Barton, Patricia; Chocron, Sheryl E.; Kim, Eunkyoung; Kelly, Deanna L.; Payne, Gregory F.; Ben-Yoav, Hadar; Ghodssi, Reza (Multidisciplinary Digital Publishing Institute (MDPI), 2017-08-01)
    Clozapine (CLZ), a dibenzodiazepine, is demonstrated as the optimal antipsychotic for patients suffering from treatment-resistant schizophrenia. Like many other drugs, understanding the concentration of CLZ in a patient’s ...
  • Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific 

    Tostanoski, Lisa H.; Chiu, Yu-Chieh; Gammon, Joshua M.; Simon, Thomas; Andorko, James I.; Bromberg, Jonathan S.; Jewell, Christopher M. (Cell Press, 2016-09-13)
    Many experimental therapies for autoimmune diseases, such as multiple sclerosis (MS), aim to bias T cells toward tolerogenic phenotypes without broad suppression. However, the link between local signal integration in lymph ...
  • Lipid tethering of breast tumor cells enables real-time imaging of free-floating cell dynamics and drug response 

    Chakrabarti, Kristi R.; Andorko, James I.; Whipple, Rebecca A.; Zhang, Peipei; Sooklal, Elisabeth L.; Martin, Stuart S.; Jewell, Christopher M. (Impact Journals, 2016-02-08)
    Free-floating tumor cells located in the blood of cancer patients, known as circulating tumor cells (CTCs), have become key targets for studying metastasis. However, effective strategies to study the free-floating behavior ...

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