Fischell Department of Bioengineering
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Induced pluripotent stem cell-derived cells model brain microvascular endothelial cell glucose metabolism (Springer Nature, 2022-12-09)Glucose transport from the blood into the brain is tightly regulated by brain microvascular endothelial cells (BMEC), which also use glucose as their primary energy source. To study how BMEC glucose transport contributes ...
Acquired Platelet And Neutrophil Dysfunction Due To High Mechanical Shear Stress (2022)Heart failure (HF) is a public health burden. In the next ten years, 8 million Americans are expected to have HF. A subset of these patients will develop advanced HF. They are refractory to medical therapies and have limited ...
Assessment of Mechanical Cues to Enhance the Clinical Translation of Extracellular Vesicles (2022)Mesenchymal stem cells (MSCs) are a common source for cell-based therapies due to their innate regenerative properties. However, these cells often die shortly after injection and, if they do survive, run the risk of forming ...
ENGINEERING LIGHT-ACTIVATABLE NANOCOMPLEX TO OVERCOME MULTIDRUG RESISTANCE AND IMPROVE DRUG DELIVERY (2022)Chemotherapy remains the main strategy for combating cancer, despite significant advances in alternative treatment modalities. It has been estimated that up to 90% of cancer-related deaths are caused by chemotherapy failure ...
Quantitative Motion Analysis of the Upper Limb: Establishment of Normative Kinematic Datasets and Systematic Comparison of Motion Analysis Systems (2022)Upper limb prosthetic devices with advanced capabilities are currently in development. With these advancements brings to light the importance of objectively and quantitatively measuring effectiveness and benefit of these ...