This paper describes a neural network-based design similarity measure for a variant fixture planning approach. The goal is to retrieve, for a new product design, a useful fixture from a given set of existing designs and their fixtures. However, since calculating each fixture feasibility and then determining the necessary modifications for infeasible fixtures would require too much effort, the approach searches quickly for the most promising fixtures. The proposed approach uses a design similarity measure to find existing designs that are likely to have useful fixtures. The use of neural networks to generate design similarity measures is explored.This paper describes the back-propagation algorithm for network learning and highlights some of the implementation details involved. The neural network-based design similarity measure is compared against other measures that are based on a single design attribute.