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Variations in 11B-Hydroxysteroid Dehydrogenase Type1 in Two Rat Models of Obesity

dc.contributor.advisorCastonguay, Thomas Wen_US
dc.contributor.authorParsons, Erica Zageren_US
dc.date.accessioned2006-06-14T06:04:33Z
dc.date.available2006-06-14T06:04:33Z
dc.date.issued2006-05-04en_US
dc.identifier.urihttp://hdl.handle.net/1903/3582
dc.description.abstractObesity is an epidemic that has been estimated to cost the United States over $117 billion every year. Glucocorticoids have long been implicated in the maintenance of energy homeostasis due to their involvement with the hypothalamic-pituitary-adrenal axis. 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) is an enzyme that interconverts the glucocorticoids cortisol and cortisone, and their rat counterparts corticosterone and 11-dehydrocorticosterone. We predicted an association between hepatic levels of this enzyme and either genetic obesity or dietary-induced obesity from any of two fat levels (high fat, low fat) or three fat sources (saturated, polyunsaturated, or monounsaturated). Our results indicated that hepatic 11β-HSD-1 is downregulated in genetic obesity, as has been previously found. High fat diets also caused reductions in hepatic enzyme message, although these were not statistically significant. There did not appear to be any effect of fat type.en_US
dc.format.extent467092 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.titleVariations in 11B-Hydroxysteroid Dehydrogenase Type1 in Two Rat Models of Obesityen_US
dc.typeThesisen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentNutritionen_US
dc.subject.pqcontrolledBiology, Microbiologyen_US
dc.subject.pquncontrolledHSD-1en_US
dc.subject.pquncontrolledhydroxysteroid dehydrogenaseen_US
dc.subject.pquncontrolledobesityen_US
dc.subject.pquncontrolledglucocorticoids;en_US


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