Show simple item record

dc.contributor.advisorHaag, Eric Sen_US
dc.contributor.authorKelleher, Danielle Fayen_US
dc.date.accessioned2006-02-04T07:58:41Z
dc.date.available2006-02-04T07:58:41Z
dc.date.issued2005-12-12en_US
dc.identifier.urihttp://hdl.handle.net/1903/3260
dc.description.abstractIn order to aid in the reconstruction of the <em>Caenorhabditis briggsae</em> sex determination pathway, for the purposes of studying the convergent evolution of hermaphroditism and mating system change in nematodes, <em>Cb-tra</em> mutants have been isolated through forward mutagenesis. Based on phenotype, genetic linkage, molecular linkage, and in some cases sequence analysis, the <em>C. briggsae</em> homologs of <em>tra-1</em>, <em>tra-2</em>, and possibly <em>tra-3</em> have been identified. Upon further characterization, the function of the <em>tra</em> genes during sex determination between <em>C. elegans</em> and <em>C. briggsae</em> appears to be largely conserved. However, notable differences, with respect to the role of <em>tra-1</em> and potentially the role of <em>tra-3</em>, have been observed between these two species. In addition, intra-species suppression of the putative <em>tra-3</em> mutant (AF16 background) by genomic variants in the wild-type strain HK104 suggests that molecular interactions underlying sex determination are changing between these two <em>C. briggsae</em> populations.en_US
dc.format.extent12492926 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.titleISOLATION AND CHARACTERIZATION OF CAENORHABDITIS BRIGGSAE TRA MUTANTS.en_US
dc.typeThesisen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentBiologyen_US
dc.subject.pqcontrolledBiology, Generalen_US
dc.subject.pqcontrolledBiology, Geneticsen_US
dc.subject.pqcontrolledBiology, Molecularen_US
dc.subject.pquncontrolledSex Determinationen_US
dc.subject.pquncontrolledNematodesen_US
dc.subject.pquncontrolledC. briggsaeen_US
dc.subject.pquncontrolledC. elegansen_US
dc.subject.pquncontrolledTRAen_US
dc.subject.pquncontrolledEvolutionen_US
dc.subject.pquncontrolledDevelopmenten_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record