In the mid- to late 1960s, as her previously underrecognized work as a painter started to secure visibility in the art world, the American portraitist Alice Neel (1900-1984) began to minimize her subjects’ physical environments, often leaving the surrounding area a blank white field. She instead concentrated her paint within the figure, the boundaries of which became emphasized by a vivid blue outline. This attention to the figure and its borders reveals a critical nuancing of the humanist ideals her paintings purportedly defended. Rather than merely affirming the autonomy of the human subject, Neel's late portraits suggest an anxiety toward the coherence of selfhood and its sheltering within the body. This essay considers a small selection of these paintings, created between 1965 and 1982, alongside the work of preceding and contemporary artists who used portraiture to work through Western culture’s shifting conceptions of the human subject to different ends. These studies ultimately explore the possibilities and limitations of portraiture in revealing and validating the subject, and how these challenges were negotiated by Neel during the culturally transformative decades which coincided with her late career.