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Development of single-neuron proteomics by mass spectrometry for the mammalian brain.

dc.contributor.advisorNemes, Peteren_US
dc.contributor.authorChoi, Bok Dongen_US
dc.date.accessioned2022-06-20T05:31:04Z
dc.date.available2022-06-20T05:31:04Z
dc.date.issued2021en_US
dc.identifierhttps://doi.org/10.13016/vpwu-ehsp
dc.identifier.urihttp://hdl.handle.net/1903/28866
dc.description.abstractSingle-neuron proteomics holds the potential to advance our understanding of important biological processes during neuron maturation and development. However, to characterize proteins from single neurons, further technological advances are still required. This dissertation discusses the development and application of single-cell mass spectrometry (MS) technologies to investigate proteins and its role in different neurons. The work presented herein demonstrates the strategies to develop and advance single-neuron analysis using capillary electrophoresis (CE)-MS. In addition, this work features several contributions to our understanding of neuron-to-neuron heterogeneity, providing new information to advance cell biology and neuroscience.en_US
dc.language.isoenen_US
dc.titleDevelopment of single-neuron proteomics by mass spectrometry for the mammalian brain.en_US
dc.typeDissertationen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentChemistryen_US
dc.subject.pqcontrolledChemistryen_US
dc.subject.pquncontrolledCapillary Electrophoresisen_US
dc.subject.pquncontrolledMass Spectrometryen_US
dc.subject.pquncontrolledNeuronen_US
dc.subject.pquncontrolledProteomicsen_US


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