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    Genomic characterization of the Yersinia genus

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    1471-2164-11-107.pdf (721.5Kb)
    No. of downloads: 28

    External Link(s)
    https://doi.org/10.1186/gb-2010-11-1-r1
    Date
    2010-01-04
    Author
    Chen, Peter E
    Cook, Christopher
    Stewart, Andrew C
    Nagarajan, Niranjan
    Sommer, Dan D
    Pop, Mihai
    Thomason, Brendan
    Thomason, Maureen P Kiley
    Lentz, Shannon
    Nolan, Nichole
    Sozhamannan, Shanmuga
    Sulakvelidze, Alexander
    Mateczun, Alfred
    Du, Lei
    Zwick, Michael E
    Read, Timothy D
    Citation
    Chen, P.E., Cook, C., Stewart, A.C. et al. Genomic characterization of the Yersinia genus. Genome Biol 11, R1 (2010).
    DRUM DOI
    https://doi.org/10.13016/2cux-ec5r
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    Abstract
    New DNA sequencing technologies have enabled detailed comparative genomic analyses of entire genera of bacterial pathogens. Prior to this study, three species of the enterobacterial genus Yersinia that cause invasive human diseases (Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica) had been sequenced. However, there were no genomic data on the Yersinia species with more limited virulence potential, frequently found in soil and water environments. We used high-throughput sequencing-by-synthesis instruments to obtain 25- to 42-fold average redundancy, whole-genome shotgun data from the type strains of eight species: Y. aldovae, Y. bercovieri, Y. frederiksenii, Y. kristensenii, Y. intermedia, Y. mollaretii, Y. rohdei, and Y. ruckeri. The deepest branching species in the genus, Y. ruckeri, causative agent of red mouth disease in fish, has the smallest genome (3.7 Mb), although it shares the same core set of approximately 2,500 genes as the other members of the species, whose genomes range in size from 4.3 to 4.8 Mb. Yersinia genomes had a similar global partition of protein functions, as measured by the distribution of Cluster of Orthologous Groups families. Genome to genome variation in islands with genes encoding functions such as ureases, hydrogeneases and B-12 cofactor metabolite reactions may reflect adaptations to colonizing specific host habitats. Rapid high-quality draft sequencing was used successfully to compare pathogenic and non-pathogenic members of the Yersinia genus. This work underscores the importance of the acquisition of horizontally transferred genes in the evolution of Y. pestis and points to virulence determinants that have been gained and lost on multiple occasions in the history of the genus.
    URI
    http://hdl.handle.net/1903/28141
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    DRUM is brought to you by the University of Maryland Libraries
    University of Maryland, College Park, MD 20742-7011 (301)314-1328.
    Please send us your comments.
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