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Modulation of Human Tumor Suppressor Genes, Gadd45, p53 and p38 MAPK by Zinc Status in Normal Human Bronchial Epithelial Cells
The effect of zinc status on the cell signaling transduction of tumor suppressor genes, Growth Arrest and DNA Damage inducible gene (Gadd45), p53, and p38 Mitogen Activated Protein Kinase (MAPK) were examined in Normal ...
Modulation of p21 Human Tumor Suppressor Gene Expression By Zinc Status In Human Hepatoblastoma And Normal Human Bronchial Epithelial Cells
The transcriptional regulation of p21 gene in both human hepatoblastoma (HepG2) cells and normal human bronchial epithelial (NHBE) cells in response to different zinc status has been examined. In both zinc deficient (ZD) ...
High Sucrose, Fructose, and Glucose Diets and Glucocorticoid Dysregulation in Rats
Approximately two-thirds of U.S. adults are overweight or obese and the prevalence of overweight in children has tripled since 1980. Intake of added sugars has also increased. The etiology of obesity remains unclear and ...
HOW SELENIUM MODIFIES CROSS-TALK BETWEEN THE PIKK FAMILY AND INSIGHTS ON THE REGULATION OF DNA-PKcs
We recently found that ATM is required for a selenium-induced senescence response in non-cancerous cells. We hypothesize the selenium-induced DNA damage response modifies ATM and DNA-PKcs cross-talk. Phospho-specific ...
THE EFFECTS OF OBESITY ON PLASMA LEVELS OF OMENTIN, A DEPOT-SPECIFIC ADIPOCYTOKINE
Obesity is a chronic pathological condition and a risk factor for diabetes and cardiovascular disease. It has been demonstrated that adipose tissue functions not only as a fat storage depot but also as an endocrine organ. ...