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Nutritional roles of selenium in cellular and mouse aging
Oxidative stress and persistent DNA damage response can lead to cellular senescence and aging. The ATM kinase and p53 protein play critical roles in the DNA damage response to reactive oxygen species and other DNA-damaging ...
ANTICANCER MECHANISM OF TOLFENAMIC ACID IN COLORECTAL CANCER
Colorectal cancer (CRC) is the third leading cause of cancer-related death in the United States. Chemopreventive therapies could be effective way to treat CRC. Tolfenamic acid, one of the NSAIDs, shows anti-cancer activities ...
TRPV4, a calcium-permeable channel, regulates oxidized LDL-induced macrophage foam cell formation
Accumulation of lipid-laden “macrophage foam cell” in the arterial wall is the hallmark of atherosclerosis that leads to the highest number of cardiovascular disease-related deaths in United States. Membrane scavenger ...
Identification of ESE-1 as a novel molecular target of chemopreventive agents for colon cancer prevention
Epithelial specific ETS-1 (ESE-1) is one of the E26 transformation-specific transcription factor superfamily and could be considerable interest as a possible target for regulating diverse types of human cancer. Despite its ...