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Methylseleninic Acid Sensitizes Notch 3-activated OVCA429 Ovarian Cancer Cells to Carboplatin
Ovarian cancer is the deadliest of gynecologic cancers and is usually diagnosed at advanced stage due to invalidated screening test. Although carboplatin has been used for treating ovarian cancer for years, high-grade ...
EFFECT OF DIETARY SELENIUM STATUS ON T CELL IMMUNITY AND CANCER XENOGRAFT IN NUDE MICE
Selenium (Se) is known to regulate carcinogenesis and immunity at nutritional and supranutritional levels. Because the immune system provides one of the main body defenses against cancer, we asked whether T cell immunity ...
Selenium compounds activate early barriers of tumorigenesis
Selenium chemoprevention by apoptosis has been well studied, but it is not clear whether selenium can activate early barriers of tumorigenesis, namely senescence and DNA damage response. To test this hypothesis, we treated ...
HOW SELENIUM MODIFIES CROSS-TALK BETWEEN THE PIKK FAMILY AND INSIGHTS ON THE REGULATION OF DNA-PKcs
We recently found that ATM is required for a selenium-induced senescence response in non-cancerous cells. We hypothesize the selenium-induced DNA damage response modifies ATM and DNA-PKcs cross-talk. Phospho-specific ...