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EFFECTS OF SUGAR SOLUTIONS ON HYPOTHALAMIC APPETITE REGULATION
There are multiple hypotheses for the causes of the obesity epidemic. One such hypothesis is that dietary intake patterns have significantly shifted to include unprecedented amounts of refined sugar. We set out to determine ...
Selenium-induced senescence involves heterochromatin formation
Abstract We have recently shown that selenium compounds can induce a senescence response in a manner depending on ataxia-telangiectasia mutated (ATM), DNA-dependent protein kinase (DNA-PK), p53 and reactive oxygen species ...
THE PROATHEROGENIC ROLE OF THE TRPV4 CALCIUM-PERMEABLE CHANNEL IN MACROPHAGES
Atherosclerosis is a multi-faceted chronic disease and one of the leading causes of cardiovascular diseases which attribute to 28.2% of all-cause mortality worldwide. Central tenets of atherogenesis are macrophage passage ...
Identification of ESE-1 as a novel molecular target of chemopreventive agents for colon cancer prevention
Epithelial specific ETS-1 (ESE-1) is one of the E26 transformation-specific transcription factor superfamily and could be considerable interest as a possible target for regulating diverse types of human cancer. Despite its ...
Role of Transient Receptor Potential Vanilloid 4 (TRPV4) Calcium-permeable Channels in Fibro-inflammatory Diseases
Tissue fibrosis and foreign body response (FBR) have emerged as two major public health problems globally over the last few decades. While fibrosis is an outcome of a dysregulated wound healing process, FBR, a chronic ...