Research has repeatedly shown that women with disabilities are more disadvantaged than both disabled men and non-disabled women due to the impacts of sexism and disability discrimination in different societies. In this dissertation study, I aim to add to the global body of literature and empirical research in the field of disability and gender. Currently, there is relatively little research focusing on the lives of women with disabilities in China. By examining the life courses and experiences of six Chinese women with disabilities, I explore how societies impact people’s experiences and how the disabled women negotiate their identities and deal with the multiple oppressions situated in their respective social positions. Research questions that guide this dissertation include: What is the general situation for women with disabilities in China? What are the experiences for women with disabilities in different aspects of their life, e.g., education, relationships, employment, family life, and social activism? To answer these questions, a qualitative multi-case study approach was adopted. Data collection consisted of multiple individual interviews, in order to study challenges that women with disabilities face, as well as their aspirations in their life courses. An overlapping conceptual framework combining a feminist perspective, critical disability lens, symbolic interactionism, and life course perspective was used to conduct a close examination of the issues concerning disabled women. The study traces important developments within the historical context for women with disabilities in China. The findings of the study reveal deeply embedded biases and discriminations in the social, political, economic, and educational systems of China; these biases and resultant discrimination manifest in disabled women’s everyday life experiences. The study also documents key life events and factors that empower women with disabilities to exert agencies in their educational and career courses. Findings of this study will be useful for government, disabled persons’ organizations, related civil society organizations engaged in disability and gender work, and disabled women in general.