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The Impacts of Branched Chain Amino Acid Supplementation on Adipocyte Function

dc.contributor.advisorSunny, Nishanth Een_US
dc.contributor.authorGregory, Tabithaen_US
dc.date.accessioned2021-09-16T05:32:00Z
dc.date.available2021-09-16T05:32:00Z
dc.date.issued2021en_US
dc.identifierhttps://doi.org/10.13016/webw-ez8q
dc.identifier.urihttp://hdl.handle.net/1903/27709
dc.description.abstractThe branched chain amino acids (BCAAs) are three essential amino acids: valine, leucine, and isoleucine. Adipose tissue has high rates of BCAA degradation and this has been shown to fuel normal function. Recent literature highlights cross- talk between BCAAs, lipid metabolism, and mitochondrial dysfunction. The objective of this thesis is to determine the impact of BCAA supplementation on adipose development, morphology, and various aspects of energy metabolism including BCAA degradation and lipolysis.C57-BL6N mice were reared on either low-fat (LF), LF with 150% BCAAs (LB), high-fat (HF), or HF with 150% BCAAs (HB) diets for 12-34 weeks. Adipose tissue morphology and energetics were determined. Results demonstrated that BCAA supplementation reduced lipid storage in visceral adipose depots, lowered circulating leptin, and reduced lipid accumulation in brown adipose tissue. BCAA supplementation also induced lipolysis, which raised circulating fatty acids. These results could have implications in the treatment and prevention of metabolic diseases.en_US
dc.language.isoenen_US
dc.titleThe Impacts of Branched Chain Amino Acid Supplementation on Adipocyte Functionen_US
dc.typeThesisen_US
dc.contributor.publisherDigital Repository at the University of Marylanden_US
dc.contributor.publisherUniversity of Maryland (College Park, Md.)en_US
dc.contributor.departmentAnimal Sciencesen_US
dc.subject.pqcontrolledAnimal sciencesen_US
dc.subject.pqcontrolledNutritionen_US
dc.subject.pquncontrolledadipocyte functionen_US
dc.subject.pquncontrolledadiposeen_US
dc.subject.pquncontrolledBranched chain amino acidsen_US


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