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Enhancing anti-tumor immunity through local gene delivery to lymph nodes

dc.contributor.authorDold, Neil M
dc.contributor.authorJewell, Christopher M
dc.identifier.citationDold, N.M., Jewell, C.M. Enhancing anti-tumor immunity through local gene delivery to lymph nodes. j. immunotherapy cancer 3, P431 (2015).en_US
dc.description.abstractBiodegradable polymer carriers offer attractive features for therapeutic cancer vaccines including delivery of multiple vaccine components, efficient internalization, and sustained release of adjuvants and tumor-associated antigens (TAAs). We previously demonstrated that local delivery of depots containing nucleic acid-based toll-liked receptor agonists (TLRas) to lymph nodes (LNs) potently enhances antigen-specific T cell immunity. Building on this work, we hypothesized that local LN delivery of microparticles loaded with TAA-encoding plasmid DNA (pDNA) and TLRas might drive strong local expression and presentation of antigen by LN-resident antigen presenting cells. These effects could help drive more potent and effective CD8+ T cell functions that slow or stop tumor growth.
dc.publisherSpringer Natureen_US
dc.subjectVaccine Componenten_US
dc.subjectDendritic Cell Activationen_US
dc.subjectMurine Splenocytesen_US
dc.subjectAssess Gene Expressionen_US
dc.subjectTherapeutic Cancer Vaccineen_US
dc.titleEnhancing anti-tumor immunity through local gene delivery to lymph nodesen_US
dc.relation.isAvailableAtA. James Clark School of Engineeringen_us
dc.relation.isAvailableAtFischell Department of Bioengineeringen_us
dc.relation.isAvailableAtDigital Repository at the University of Marylanden_us
dc.relation.isAvailableAtUniversity of Maryland (College Park, MD)en_us

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