Browsing Chemistry & Biochemistry Theses and Dissertations by Title
Now showing items 1-20 of 513
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5-MODIFIED LIPOPHILIC G-QUADRUPLEXES: STRUCTURAL STUDIES AND APPLICATIONS AS SCAFFOLDS FOR [2+2] PHOTOCYCLOADDITIONS
(2019)Guanosine self-assembly is a powerful tool for constructing nanostructures and materials with intriguing properties. Guanosine’s nucleobase has a hydrogen bond donor and acceptor face that in the presence of an appropriate ... -
Activation, Multiple-Bond Cleavage, and Fixation of Small Molecules Employing Group 6 Cyclopentadienyl, Amidinate (CpAm) Complexes
(2012)Small molecules (e.g. N2, CO2, N2O) represent potential cheap and abundant chemical feedstocks. Despite the use of small molecules in various biosynthetic pathways, relatively few synthetic processes for the commercial ... -
Acyclic Congeners of Cucurbit[n]uril and a Related Mechanistic Study on the Cucurbit[n]uril Forming Reaction.
(2010)Supramolecular chemistry has been a very important research area in the past several decades. In this research field, molecular containers, such as cyclodextrin, attracts special attention due to their wide applications ... -
ACYCLIC CUCURBIT[N]URIL CONGENERS: SYNTHESIS, BINDING PROPERTIES AND MEDICINAL APPLICATIONS
(2014)An urgent problem for pharmaceutical industry is that the water solubility of an estimated 40-70% of the newly developed active pharmaceutical ingredients (API) are so poor that they cannot be formulated on their own. One ... -
ADSORPTION AND MECHANISTIC STUDIES OF DIMETHYL METHYLPHOSPHONATE FOR CWA DEFEAT
(2018)This thesis work systematically investigated carefully designed ASZM- TEDA deconstruction–reconstruction experiments. Our objective is to understand the role of each impregnant, the factors that influence filter performance, ... -
Advanced Receptor Models for Exploiting Highly Time Resolved Data Acquired in the EPA Supersite Project
(2012)Receptor models have been widely used in air quality studies to identify pollution sources and estimate their contributions. A common problem for most current receptor models is insufficient consideration of realistic ... -
ADVANCES IN SILOXANE-BASED COUPLING TECHNOLOGIES: APPROACHES TOWARD PANCRATISTATIN AND STREPTONIGRIN
(2014)The ability to form carbon-carbon bonds, arguably the most important transformation in synthetic chemistry, has been critically facilitated via the implementation of transition metal catalysts with main group element-associated ... -
AEROBIC OXIDATION OF CIS-2-BUTENE AND 2-BUTYNE IN WATER MEDIATED BY (DPMS)PtII (DPMS = DI(2-PYRIDYL) METHANE SULFONATE)
(2010)(dpms)Pt<super>II</super> hydroxo ethylene complex <bold>(2.1)</bold> undergoes ligand substitution--intramolecular hydroxo platination with 2-butyne in water to give Pt<super>II</super> η<super>1<super/>-ketonyl ... -
Airborne Characterization of Regional Aerosol Origins and Optical Properties
(2004-08-31)The ubiquity of air pollution in the Mid-Atlantic and northeastern U.S. is a major concern for human and ecological health as well as the climate. Between February 2001 and February 2004, 160 flights on a light aircraft ... -
ALKYNYL AMINOISOQUINOLINES, NOVEL FLT3 KINASE INHIBITORS WITH POTENT ACTIVITY AGAINST ACUTE MYELOID LEUKEMIA
(2018)Acute myeloid leukemia (AML) is a type of blood cancer. If not properly treated, this subclass of leukemia can progress quickly, and be fatal after a few months. Aberrantly expressed FMS (Feline McDonough Sarcoma)-like ... -
Allostery and GroEL: Exploring the Tenets of Nested Cooperativity
(2004-06-24)Despite a wealth of structural and biochemical studies on the functional cycle of the <i>E. coli</i> chaperonins GroEL and GroES, no model proposed to date accounts for all the effects seen experimentally by ... -
Allostery in GroEL: Its Role in the Refolding of Protein Substrates
(2003-12-01)The Escherichia coli chaperonin GroEL assists in the re-folding of misfolded substrate proteins (SPs). In response to the binding of ATP, GroEL undergoes large, allosteric structural transitions, resulting in an expansion ... -
Alterations in the Primary Structures of Ribosomal Proteins in Acquired Drug Resistance
(2012)Acquired drug resistance is a multifactorial process that is one of the major causes for cancer treatment failure. The anticancer drug, mitoxantrone, was recently determined to inhibit ribosome biogenesis. Changes in ... -
Amidinate Based Catalysts for the Stereospecific and Living Ziegler-Natta Polymerization of Alpha-Olefins
(2003-12-04)The living Ziegler-Natta polymerization of alpha-olefins has been accomplished with a series of precatalysts based on cyclopentadienyl and pentamethylcyclopentadienyl zirconium amidinates (Cp and Cp*ZA's, respectively) ... -
Analysis of Genetic Regulatory Mechanisms that Control Ethanolamine Utilization in Enterococcus faecalis
(2017)In this project, we studied the genetic regulatory mechanisms that affect utilization of ethanolamine, an abundant compound in the gastrointestinal environment. In Enterococcus faecalis, the ethanolamine utilization (eut) ... -
Analysis of Intact Proteins in Complex Mixtures
(2013)Our goal is to develop an effective work flow for analysis of intact proteins in a complex mixture using the LC-LTQ-Orbitrap XL. Intact protein analysis makes the entire sequence available for characterization, which allows ... -
An Analysis of the Stability, Aggregation Propensity, and Negative Cooperativity of the Escherichia coli Chaperonin GroEL
(2013)Since the discovery of chaperonin GroEL and co-chaperonin GroES, there has been a deluge of literature investigating many aspects of the system. Substrate proteins are protected from aggregation through a cycle of capture, ... -
AN APPARATUS FOR LIGHT-LESS ARTIFICIAL GAUGE FIELDS AND NEW IMAGING TECHNIQUES
(2015)The thesis presented has three components: experiments with artificial vector potentials, a new atom-chip apparatus designed and built for light-less fictitious gauge fields, and an imaging experiment. First, we introduce ... -
APPLICATION OF FLUCTUATION ANALYSIS TO CHARACTERIZE MULTI-SCALE NATURE AND PREDICTABILITY OF COMPLEX SYSTEMS
(2014)Complexity is a result of interactions among individual components of a distributed system, each with their own dynamical time scale. Statistical techniques such as fluctuation analysis are used to quantify extent of ... -
Application of Silicon-Based Cross-Coupling Technology to Aryl Triflates
(2004-05-06)The goal of this research was to explore the use of aryl silatranes as a replacement for aryl siloxanes in the palladium-catalyzed cross-coupling reaction with aryl triflates. Phenylsilatrane underwent fluoride-induced ...