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Cytotoxic T lymphocytes (CTLs) play a critical role in controlling intracellular pathogens and cancer cells, and induction of memory CTLs holds promise for developing effective vaccines against critical virus infections. ...

Continued improvements in embryo culture media composition allow for the growth of high quality blastocysts, which can be used to derive embryonic stem cells (ESCs). ESCs are capable of becoming any cell type in the body ...

Neural crest cells are a population of multi-potent progenitor cells in the developing vertebrate embryo that undergo an epithelial-to-mesenchymal transition (EMT) and migrate extensively to generate diverse derivatives. ...

Rivulus is a hermaphroditic, self-fertilizing fish species that possesses an ovotestis and, in the wild, exist as androdioecious populations comprised of hermaphrodites and males. Following embryonic incubation at an ...

The aim of this thesis was to identify protein factors that may regulate the size of lipid droplets in milk. To address this hypothesis, the relative amounts of specific MFGM proteins on lipid droplets fractionated according ...

Cytotoxic T cell (CTL) is the key to induce an effective immune response against infections caused by intracellular pathogens, such as virus and cancer. CTLs with low affinity can induce and maintain a substantial population ...

Epigenetic modifications constitute a complicated regulatory network controlling various biological processes from cell development to immune responses. The mechanisms through which CD4+ T cells react to environmental ...

The cranial sensory ganglia are created from neural crest cells and placode cell-derived neurons. Defects in the migration and interaction of these cells can cause abnormalities in craniofacial development and the sensory ...

My thesis was focused on the role of Comparative Gene Identification-58 (CGI-58)-mediated adipocyte lipid droplet (LD) lipolysis in thermogenesis and metabolic health. LD lipolysis in energy-dissipating brown adipose tissue ...

Heme is an essential cofactor in numerous proteins, but is also cytotoxic. Thus, directed pathways must exist for regulating heme homeostasis. C. elegans is a powerful genetic animal model for elucidating these pathways ...