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Identification and characterization of long intergenic noncoding RNAs associated with Marek's disease resistance in chicken
Marek's disease (MD) is a highly contagious lymphomatous disease of chicken caused by Marek's disease virus (MDV). MDV has steadily evolved toward increased resistance and virulence over the past decades. A promising ...
The role of interleukin-12 for mTOR regulation of memory CTLs
A major goal of vaccines is to induce functional immune memory, and efforts to improve the efficacy of vaccines targeting memory CTLs have revealed an important immunoregulatory role of rapamycin, a specific mTOR inhibitor. ...
In Vitro Study of an Orange Oil Derived Alternative to Antibiotics in the Treatment of Bovine Mastitis
Bovine mastitis is a costly disease in the U.S. dairy industry. Its major causative agent Staphylococcus aureus is often unresponsive to antibiotic therapy. Our first study examined terpeneless, cold-pressed Valencia ...
Lineage reprogramming of tumor-infiltrating cytotoxic T lymphocytes using protein stem cell transcription factors
Adoptive cell transfer therapy (ACT) is one of the most promising immunotherapies against cancer. However, this treatment regimen requires the expansion of a small population of effector cells, known as tumor infiltrating ...
GENOME-WIDE ANALYSIS OF CHICKEN MIRNAS AND DNA METHYLATION AND THEIR ROLES IN MAREK'S DISEASE RESISTANCE AND SUSCEPTIBILITY
Marek's disease (MD) is a T cell lymphoma in chickens and causes high mortality and morbidity in productive chickens. Two inbred chicken lines, resistant line 63 and susceptible line 72, with the same MHC haplotype, showed ...