Now showing items 1-4 of 4
LONG-RANGE SIGNALING AT THE INTESTINAL-NEURAL AXIS PROMOTES ORGANISMAL HEME HOMEOSTASIS IN C. ELEGANS
Metazoans synthesize and regulate intracellular heme in a cell autonomous manner although genetic evidence in vertebrates suggests that cell non-autonomous mechanisms may exist at the organismal level. In <italic>C. ...
MOLECULAR MECHANISMS UNDERLYING CADHERIN-6B INTERNALIZATION IN PREMIGRATORY CRANIAL NEURAL CREST CELLS DURING THEIR EPITHELIAL-TO-MESENCHYMAL TRANSITION
The generation of migratory cells from immotile precursors occurs frequently throughout development and is crucial to the formation and maintenance of a functioning organism. This phenomenon, called an epithelial-to-mesenchymal ...
THE REGULATION OF THE INTESTINAL COPPER EXPORTER IS COORDINATED WITH SYSTEMIC COPPER HOMEOSTASIS
Copper (Cu) plays key catalytic and regulatory roles in biochemical reactions essential for normal growth, development, and health. Defects in Cu metabolism cause Menkes and Wilson’s disease, myeloneuropathy, and cardiovascular ...
FUNCTIONAL CHARACTERIZATION OF HEME TRANSPORTERS IN ZEBRAFISH
Hrg1 and Mrp5 are identified as eukaryotic heme importer and exporter, respectively. Two Hrg1 paralogs have been annotated in zebrafish genome, Hrg1a (Slc48a1b) and Hrg1b (Slc48a1a) with 84% homology in protein sequences. ...