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OPTIMIZING GENE TARGETING METHODOLOGIES USING CRISPR/CAS RIBONUCLEOPROTEINS IN PORCINE SOMATIC CELLS
The pig is one of the most valuable animal models for agricultural and biomedical research. In this thesis, we sought to standardize procedures for routine gene targeting and demonstrate that it is possible to create ...
Genetic Suppressors of mrp-5 Lethality in C. elegans
Heme is an essential cofactor in numerous proteins, but is also cytotoxic. Thus, directed pathways must exist for regulating heme homeostasis. C. elegans is a powerful genetic animal model for elucidating these pathways ...