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FUNCTIONAL INSIGHTS INTO HRG-1-MEDIATED HEME TRANSPORT
(2012)
Heme is an essential cofactor involved in various biological processes including oxygen transport, xenobiotic detoxification, oxidative metabolism, gas sensing, circadian rhythm, signal transduction, microRNA processing ...
The role of the adherens junction protein alphaN-catenin in neural crest-derived trigeminal ganglia formation
(2012)
Neural crest cells (NCCs), a transient, multipotent population of cells that arise during neurulation, are a class of cells crucial to normal vertebrate development. NCCs must be tightly regulated by molecular and structural ...
LONG-RANGE SIGNALING AT THE INTESTINAL-NEURAL AXIS PROMOTES ORGANISMAL HEME HOMEOSTASIS IN C. ELEGANS
(2014)
Metazoans synthesize and regulate intracellular heme in a cell autonomous manner although genetic evidence in vertebrates suggests that cell non-autonomous mechanisms may exist at the organismal level. In <italic>C. ...
MOLECULAR MECHANISMS UNDERLYING CADHERIN-6B INTERNALIZATION IN PREMIGRATORY CRANIAL NEURAL CREST CELLS DURING THEIR EPITHELIAL-TO-MESENCHYMAL TRANSITION
(2015)
The generation of migratory cells from immotile precursors occurs frequently throughout development and is crucial to the formation and maintenance of a functioning organism. This phenomenon, called an epithelial-to-mesenchymal ...
OPTIMIZING GENE TARGETING METHODOLOGIES USING CRISPR/CAS RIBONUCLEOPROTEINS IN PORCINE SOMATIC CELLS
(2016)
The pig is one of the most valuable animal models for agricultural and biomedical research. In this thesis, we sought to standardize procedures for routine gene targeting and demonstrate that it is possible to create ...
ROLE OF ANNEXIN A6 IN SENSORY NEURONS DURING EARLY CHICK CRANIAL GANGLIA DEVELOPMENT
(2017)
The cranial sensory ganglia are created from neural crest cells and placode cell-derived neurons. Defects in the migration and interaction of these cells can cause abnormalities in craniofacial development and the sensory ...
Genetic Suppressors of mrp-5 Lethality in C. elegans
(2016)
Heme is an essential cofactor in numerous proteins, but is also cytotoxic. Thus, directed pathways must exist for regulating heme homeostasis. C. elegans is a powerful genetic animal model for elucidating these pathways ...
THE REGULATION OF THE INTESTINAL COPPER EXPORTER IS COORDINATED WITH SYSTEMIC COPPER HOMEOSTASIS
(2017)
Copper (Cu) plays key catalytic and regulatory roles in biochemical reactions essential for normal growth, development, and health. Defects in Cu metabolism cause Menkes and Wilson’s disease, myeloneuropathy, and cardiovascular ...
FUNCTIONAL CHARACTERIZATION OF HEME TRANSPORTERS IN ZEBRAFISH
(2017)
Hrg1 and Mrp5 are identified as eukaryotic heme importer and exporter, respectively. Two Hrg1 paralogs have been annotated in zebrafish genome, Hrg1a (Slc48a1b) and Hrg1b (Slc48a1a) with 84% homology in protein sequences. ...
Identification of the molecular networks governing ovulation frequency in low and high egg producing turkey hens
(2019)
Selection for carcass traits has negatively impacted and varied the reproductive efficiency of the commercial turkey hen, creating overall lowered egg production as well as distinct groups of low egg producing hens (LEPH) ...